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neoformans can disseminate to the central nervous system (CNS) by employing a Trojan horse mechanism, whereby it survives within macrophages in the bloodstream to cross the bloodbrain barrier

The resulting diminishment of Hes1 expression and other Notch effectors compromises the sphere-forming ability of CSCs and their capacity to maintain the undifferentiated state (72, 73)

Older men with comorbidities should start at lower initiation doses

J Biomed Mater Res Part B-Appl Biomater 104(5):10321042

PubMed link The authors examined time to relapse and relapse rate among benzodiazepine users who were in a supervised taper group (Taper), a cognitive-behavioral therapy group (CBT), and a Combined group receiving both interventions