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Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction

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Neutrophils contain an extensive antimicrobial arsenal that includes a) Pentraxin 3 contained in specific granules and neutrophil extracellular traps, b) elastase (a component of azurophil granules), and c) nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase

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Received 5 November 2019 Accepted for publication 27 February 2020 Published 18 June 2020 Volume 2020:13 Pages 20932108 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Ming-Hui Zou Michael Wakeman, David T Archer Faculty of Health and Wellbeing, Sciences Complex, University of Sunderland, Sunderland SR1, UK Correspondence: Michael Wakeman Faculty of Health and Wellbeing, Sciences Complex, University of Sunderland, Sunderland SR1 3SD, UK Tel +44 191 5153381 Email [email protected] Abstract: Metformin is the first-choice drug in uncomplicated type 2 diabetes (T2DM) and is effective in improving glycaemic control