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doi: 10.1098/rsos.181457 180 PatelDDesaiCSinghDSoppinaVParwaniKPatelFet al

Research Limitations and Gaps While the individual peptides have encouraging results in animal or cellular models, several limitations remain: Lack of clinical trial data on combinations or long-term effects Unknown interaction dynamics between multiple peptides in vivo Variability in peptide purity and stability among sources Dosing and timing considerations remain undefined in a blended context Limited human translational data beyond small pilot or observational studies Further research is needed to determine how such peptides behave together , including any potential synergistic , neutral , or even antagonistic interactions

Reliene R, et al

doi: 10.4314/tjpr.v15i9.12

Meaningful progress will require a paradigmatic shift towards integrated approaches

Sandoo A, van Zanten JJ, Metsios GS, Carroll D, Kitas GD