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Exposure to reactive oxygen or nitrogen species is causatively linked to the disease pathologies associated with redox imbalance

Since the FDA investigation of contaminated eye drops leading to 14 patients blindness and four peoples removal of one eye, the FDA has been diligently monitoring for nonsterile eye drops on the market

Curr Vasc Pharmacol 2012

(2) intestinal barrier disruption: pesticide and fertilizer residues may induce enteritis and impair absorption

Given that cyanide exposure from linamarin is strongly associated with the development of konzo, an increase in plasma oxidative stress may also affect cyanide action or metabolism, potentially amplifying its capacity to induce mitochondrial stress or giving rise to its oxidized form cyanate, which is a strong neurotoxin in various experimental models that can further decrease glutathione levels in the CNS 52,53

There is an increasing number of studies showing the association between neurological disorders and cognitive function and AGEs [46]