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In addition, doses proved to be efficient in preclinical research, e.g

Metabolism 70:12-22 2017 PMC5407411 Mack DL, Poulard K, Goddard MA, Latournerie V, Snyder JM, Grange RW, Elverman MR, Denard J, Veron P, Buscara L, Le Bec C, Hogrel JY, Brezovec AG, Meng H, Yang L, Liu F, O'Callaghan M, Gopal N, Kelly VE, Smith BK, Strande JL, Mavilio F, Beggs AH, Mingozzi F, Lawlor MW, Buj-Bello A, Childers MK

Essential vitamin that enhances fat metabolism and energy production at the cellular level

However, the European Food Safety Authority (EFSA), the European equivalent of the FDA, considers daily intakes of up to 5,000 mg from supplements to be safe (30)

Clin Gastroenterol Hepatol 2012;10:422-427

Strength athletes, runners, functional trainers, and anyone who wants support for blood flow, nutrient delivery, and muscle recovery