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doi: 10.1038/nrc.2016.85

Lung cancer patients face key challenges on their path to survival, such as acquired mutations, bypass activation, histological transformation, off-target effects, complex changes in the tumor immune microenvironment, and the adaptive overexpression of various immunosuppressive receptors [16]

10.1111/jnc.13410 253 RonowskaA.SzutowiczA.BielarczykH.Gul-HincS.Klimaszewska-ataJ.DyA.et al

It is also seen in other ethnic groups like Greeks, Sephardic Jews, and Sardinians

There have been also ethical issues raised [25] and considerations expressed as to whether ISS should be considered a disease, whether the degree of psychosocial morbidity warrants treatment [26-28], whether it is enhancement or endo-cosmetology rather than treatment [29], and whether treatment has any effect in health related quality of life [30-32]

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