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It is a common symptom most people have experienced at some point in their lives

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However, oxidative stress-mediated changes in cellular machinery allow Nrf2 to escape the degradation pathways and translocate to the nucleus

Hastings TG: The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson's disease

Future research should prioritize the systematic validation of the synergistic therapeutic effects of the above drugs through this signaling axis in OA animal models