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High doses of Vitamin B6 and B12 may also lead to an imbalance in the gut microbiome, which can cause inflammation in the skin and contribute to the development of Acne
Strbe et al., 2021)
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Increased collagen organization improves the structural quality of healing tissue
It had limited food-supplement GRAS history in some jurisdictions but Australia's TGA placed it on Schedule 4 (prescription) in 2020
