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Description
It works by increasing serotonin signaling in the brain

ROS production occurs in multiple ways and is quite complex, however the oxidation of glutathione was pertinent when looking at fish species in which this AOP was based

Ren J, Ren B, Fu T, Ma Y, Tan Y, Zhang S, Li Y, Wang Q, Chang X, Tong Y
Effects of cigarette smoking on Fas/Fas ligand expression of human lymphocytes

[DOI] [PMC free article] [PubMed] [Google Scholar] 142.Ferrara C.T., Boodhansingh K.E., Paradies E., Fiermonte G., Steinkrauss L.J., Topor L.S., Quintos J.B., Ganguly A., De Leon D.D., Palmieri F., et al

Precision medicine is already guiding trials for LRRK2 inhibitors, GCase modulators, and GLP-1 analogues, representing a shift toward therapies tailored to molecular etiology and patient-specific risk profiles
