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While these nanoparticles can potentially reverse MDR by modulating drug efflux pumps and apoptotic pathways, their efficacy can be reduced due to the complex heterogeneity of tumor cells and the emergence of resistance mechanisms at the cellular and molecular levels ( 7.2.3 Alternative approaches to overcome these challenges To address the challenge of variability in plant extract quality, researchers are focusing on standardization and optimization of the extraction processes

Therefore, the sustentation of DFO critical concentration is crucial for its effectiveness (Xue et al., 2016)

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To establish secondary spinal cord injury, four animals were sacrificed 10 min after spinal injury immediately prior to the administration of therapy