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Description
This phenomenon is thought to be due to the inability of cells to restore normal GSH levels or to increased production of reactive oxygen species (ROS), which can damage macromolecules fundamental to cell survival before being deactivated by antioxidant defenses

162 , 182 , 205 While these platforms often demonstrate robust in vitro activity, their in vivo efficacy remains variable due to intratumoural heterogeneity and dynamic remodelling of the protein corona

These limitations hinder the transition of ferroptosis-based strategies from invertebrate and rodent models to clinical settings

14 GhanimM.KontsedalovS.CzosnekH

& Tyagi, S

Other research has demonstrated antioxidant effects, with DSIP activating natural protective mechanisms against oxidative stress
