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Frequently used tools in GSH research and therapy are interventions that increase GSH levels [246]

Although clomipramine shows around 100- to 200-fold preference in affinity for the serotonin transporter (SERT) over the norepinephrine transporter (NET), its major active metabolite, desmethylclomipramine (norclomipramine), binds to the NET with very high affinity (K i = 0.32 nM) and with dramatically reduced affinity for the SERT (K i = 31.6 nM)

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