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If receiving cancer treatment, supplementing with Glutathione may cause drug interactions and allow cancer cells to be resistant to chemotherapy drugs, thus decreasing their effectiveness and increasing oxidative stress
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Wiley Blackwell (Oxford, UK) 2017:99126

& Shen, W
The lack of functional GSTU13 resulted in enhanced disease susceptibility toward several fungal pathogens including Erysiphe pisi, Colletotrichum gloeosporioides , and Plectosphaerella cucumerina (Pislewska-Bednarek et al., 2018)
Similarly, B is the effect of the genetic component of the second exposure on the outcome trait, after accounting for the genetic component of the first exposure and for the two exposures genetically regulated co-expression