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Furthermore, fatty acid oxidation (FAO) is markedly upregulated in resistant tumor cells, providing additional substrates such as acetyl-CoA and propionyl-CoA to fuel the TCA cycle via citrate synthase and succinyl-CoA synthesis (251, 252)

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In vitro and in vivo studies as well as postmortem observations have shown that intrinsic caspase-dependent apoptosis participates in dopaminergic cell death in PD (Hartmann et al., 2000

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doi: 10.1034/j.1399-3054.2002.1140201.x 8 Clemente-MorenoM