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However, current evidence is mainly derived from preclinical studies, and further investigations, particularly rigorous clinical trials in humans, are necessary to clarify the mechanisms involved and to evaluate their efficacy and safety in patients with cutaneous melanoma

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E.OuchiN.et al (2014)

The island was represented to be larger than Asia and Africa, as they were then known, and beyond it was a large continent

Test of independent proportions: To compare the independent relative frequencies (proportions), the Test of independent proportions was used