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In addition, melatonin is responsible for attenuating the activation of microglial and astrocyte cells, as indicated by decreased production of markers such as ionized calcium-binding adapter molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP) (Boutin et al., 2001

The molecular components of the DSB induced DDR have been studied in detail, and are typically classified into three major groups - sensors which recognize damage, transducers which coordinate signaling, and effectors which mediate eventual outcomes (Fig

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doi: 10.1016/j.autrev.2020.102664 11 WangWYueCGaoSLiSZhouJChenJet al

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Its pathogenesis is complex, involving genetics, dysregulated immune response, environmental factors, and epithelial barrier defects, and it usually occurs in the rectal and colonic mucosa [2]