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In the process of ferroptosis, PUFAs serve as major targets for lipid peroxidation

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At the end of the 1970s, it was generally accepted that DNA methylation has an important role in suppressing gene expression [16], and its role in cell differentiation has begun to crystallize after the publication of a study on undifferentiated murine embryonic cell lines treated with DNA methylation inhibitor, 5-azacytidine, in which new cell phenotypes had been formed [13, 20]