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During the differentiation of Th17 and Tregs, OXPHOS integrates with the mTOR, AMPK, and HIF-1 signaling pathways, establishing a complex metabolic regulatory network [84]
Complex human diseases, which involve feedback between many genes and cells, likely are driven by epigenetic changes and responses as well as by allelic variations
Int J Paediatr Dent 2010;20 Suppl 1:5
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Safaei R, Holzer AK, Katano K, Samimi G, Howell SB