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Lastly, combinatorial mutation of C8, C26, and C83 results in increased activity of GLRX and resistance to oxidative inactivation and aggregation

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Cardinali DP, Brusco LI, Liberczuk C, Furio AM

2.2.2 Endoplasmic reticulum: regulator of lipid metabolism and redox homeostasis The ER maintains cellular homeostasis through protein synthesis, lipid metabolism, and calcium storage ( - localized to the ER membranemediates cystine import for GSH synthesis (66)

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