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As previously stated, the TP53 mutation may play an important role in NF1-associated or sporadic MPNST, and it appears to be a marker of high tumor grade [88]
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In summary, while some patientsespecially those with sporadic, completely resected, and smaller tumorsmay achieve durable remission, malignant schwannoma remains a high-risk malignancy with limited curative options once it recurs or metastasizes
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Because the apoC-III location on chromosome 11 is near insulin response elements, a link to diabetes has been surmised [124]
