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[DOI] [PMC free article] [PubMed] [Google Scholar] 152.Wilkie D.A., Latimer C.A

Complete week-by-week combined protocol The following protocol represents a conservative approach to introducing both compounds, designed to minimize GI side effects while building toward full therapeutic doses

While P140 is not available outside clinical trials, it demonstrates that peptide-based approaches can achieve antigen-specific tolerance in lupus, precisely targeting the dysfunctional immune cells while leaving normal immune function intact

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Researchers designing studies should carefully consider the evidence gap