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Metabolomic approaches have identified unique profiles in NASH patients, with specific metabolites like ethanol linked to disease progression

Torres-Pea, Laura Martn-Piedra, Francisco Fuentes-Jimnez Frontiers in Cardiovascular Medicine.2021;[Epub] CrossRef Comparison of the liver findings after simvastatin-treatment between Spontaneously Diabetic Torii- Lepr fa (SDT fatty) rats and Sprague-Dawley rats Tadakazu Takahashi, Yusuke Suzuki, Naohito Yamada, Kaoru Toyoda, Keisuke Goda, Katsunori Ryoke, Chizuru Matsuura, Akio Kobayashi, Shoichiro Sugai, Kayoko Shimoi Fundamental Toxicological Sciences.2020

The serum concentrationdose relationship is curvilinear (e.g., the concentrationdose ratio decreases with increasing dose) probably because of increasing free concentrations and a resulting increase in clearance