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Mitochondrial genetics and obesity: evolutionary adaptation and contemporary disease susceptibility

27 However, when potential initiating events were investigated, the authors provided evidence that erastin inhibits system X c -, a Na + -independent cystine/glutamate antiporter responsible for cystine uptake into the cell, thereby promoting glutathione synthesis

Genetic ablation of the cystine transporter xCT in PDAC cells inhibits mTORC1, growth, survival, and tumor formation via nutrient and oxidative stresses

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