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In animal experiments, copper ions binding to GSH caused intracellular GSH depletion, impairing antioxidant capacity, exacerbating oxidative stress and protein nitration, and leading to neuronal damage (8)
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As a consequence of the above, an increase in the biotransformation (metabolism) of some drugs, such as phenytoin, can be observed [120,121]

and Psychiatry 62 (6), 596600

doi: 10.1371/journal.pntd.0002823 145 DongSDimopoulosG
PMCID: PMC4309183

Von Economo Neurons and Fork Cells: A Neurochemical Signature Linked to Monoaminergic Function
