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Interestingly, in traumatic brain injury, GPx1 deficiency was associated with decreased mitochondrial bioenergetic capacity compared to wildtype mice, whereas transgenic GPx1 mice had no decrease in mitochondrial function [114] GPx1 deficiency also enhanced apoptosis and inflammation in a cold-induced brain injury model [115]

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We also confirmed that NMN could promote cell death after inhibiting the apoptotic program only at the high dose (Figure 1GK)

References: Albericio, F., & Kruger, H

GSH also participates in the detoxification of hydrogen peroxide by various glutathione peroxidases
