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Running multiple compounds affecting gut function simultaneously can amplify these effects beyond tolerable levels

139,140 In PD brains, Parkin has been found to colocalize with -Syn in LBs, even though -Syn is not a substrate of Parkin

10.1073/pnas.94.6.2306 8 CairnsN

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Hormozdiari, F., Kostem, E., Kang, E
