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Any bleeding or bruising that seems unexpected

It is interesting that, same as P2Y12 blockers, Ticagrelor and Clopidogrel have the opposite role in ER stress and eNOS phosphorylation

Impaired vibration sensation and proprioception and paresthesia are unfortunately similar in both diabetic neuropathy and vitamin B 12 deficiency [71]

The tip of the microvilli is always relatively hypoxic compared to the base, and in reduced perfusion states, oxygen will tend to move down a gradient from arteriole to venule closer to the base, thus exacerbating hypoxia at the tip and potentially switching apoptosis to necrosis in epithelial cells