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539 Results from several Phase III clinical trials (ORION-9/10/11, NCT03397121, NCT03399370, and NCT03400800) have shown that subcutaneous injections of inclisiran every 6 months considerably reduce LDL-C levels by 4852%, demonstrating sustained efficacy and good tolerability

However, several theoretical indirect mechanisms warrant clinical consideration

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The maintained improvement pattern suggests GHK-Cu successfully stimulated durable structural changes in dermal architecture supporting ongoing enhanced function without continuous peptide supplementation