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This recycling loop is why B-vitamin status matters not just for synthesis but for sustaining the glutathione pool you already have
Under quiescent conditions, cytosolic Nrf2 directly binds to Kelch-like ECH-associated protein 1 (Keap1), a substrate adapter protein for the Cul3E3ligase complex, resulting in rapid degradation of Nrf2 (Ulasov et al., 2022)
Finally, compared to the R group, LC patients had 49 reduced but 111 increased metabolites ( Figure 2J )
10.1038/nature14893 Nature 46 LemastersJ
Shawnee, S)
