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He specifically warned that LPS contamination can be cumulative it is not that one injection causes a reaction, but the inflammatory load builds until a tipping point is reached

Chen C, Turnbull DM, Reeve AK

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Chronic systemic inflammation leads in acceleration of subclinical atherosclerosis [56]
Univariate logistic regression adjusted for time from symptoms onset and thrombolysis administration was used to study the association of extracted features with recanalization success, hemorrhagic transformation (HT) or both (bad outcome)

But not enough
