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Impact of Targeted Deletion of the Circadian Clock Gene Bmal1 in Excitatory Forebrain Neurons on Adult Neurogenesis and Olfactory Function

doi: 10.1016/0145-2126(95)00162-X, PMID: 10 KalaposMP
For refractory cases, the definitive interventional treatment is advanced neuromodulation

Research into peptide treatments spans back to the 19th century

[DOI] [PubMed] [Google Scholar] David LL, Shearer TR

Endogenous and exogenous cannabinoids, including nabilone, may have potential therapeutic benefits for improving sleep and relieving pain and mood disorders in PD patients through their effects on various neurotransmitter systems, including monoaminergic, GABAergic, glutamatergic, and opioid signaling