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Additionally, damaged mitochondria release mtDNA into the cytosol, activating the innate immune system via damage-associated molecular patterns (DAMPs) (251, 377), modulating both innate and adaptive immune responses (377379)

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II-1 Evidence obtained from well-designed controlled trials without randomization

Figure 2 Quantification of basal B12 Basal levels of vitamin B12 were quantified of plasma aliquots from endpoint U using the standard chemiluminescence method by a commercial clinical laboratory (Hermes Pardini, Belo Horizonte, Brazil)