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5.2.4.3 Metabolism of S -Containing Moieties 5.2.4.3.1 Metabolism via S -Oxidation Phase I metabolism for sulfur containing compounds generally proceeds via direct oxidation of the heteroatom (SET), which impacts different sulfur containing functional groups including sulfides (especially in ring structures), free thiols, sulfonyls, and thioketones

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Phosphatidylserine (PS), as a phospholipid of the renal tubular epithelial cell membrane that can adsorb crystals, flips to the cell surface, enhancing the adhesiveness of stone crystals at the flipped sites ( Joshi et al

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