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30 days (reconstituted) Mechanism Classification Primary Mechanism: NNMT (Nicotinamide N-methyltransferase) Inhibitor Target Enzyme: Nicotinamide N-methyltransferase Cellular Effect: Increases intracellular NAD+ and SAM levels Metabolic Pathway: NAD+ salvage pathway modulation Selectivity: Highly selective for NNMT (no cross-reactivity with related enzymes) Pharmacological Properties Route of Administration: Subcutaneous injection Bioavailability: High (subcutaneous)
Statements Data availability statement The trained Healthy Human Model, alongside the test-retest reliability dataset ( n = 11, each with two test-retest acquisitions) with both non-contrast scans and ground truth GBCA-uptake maps, is available on GitHub ( The scripts that predict GBCA-uptake maps from non-contrast scans, as well as the script performing quantitative evaluations, are included
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