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Nevertheless, this strategy does not allow circumventing the intrinsic instability of the maleimide moiety, which is prone to hydrolysis during its introduction via amide-coupling, during purification and bioconjugation, limiting the overall functionalisation yield 19,20

doi: 10.1007/s00223-017-0292-1

So, without GSH, the antioxidant mechanism is missing in RBCs

234 It remains to be explored whether these substitutions contribute to the etiology of folding-related diseases or whether they have other physiological functions that are not currently understood

The glutamine transporter proteins SLC1A5, SLC7A11, and GLUD can be inhibited by various compounds such as -FBP, Sulfasalazine, and epigallocatechin-3-gallate (EGCG), respectively [165,166,167]

The fundamental attributes of hydrogels lie in their three-dimensional hydrophilic polymer networks, which exhibit biocompatibility, biodegradability, and high drug-loading capacity, enabling on-demand drug release in response to environmental stimuli (e.g., pH and temperature) (Mathew et al., 2018)