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A randomized trial published in the Annals of Internal Medicine found that sleep restriction was associated with an 18% reduction in the satiety hormone leptin, a 28% rise in the hunger hormone ghrelin

2.3 Demyelination and cellularity differences between C57BL/6J and C57BL/6NTac strains Sections were semi-quantitatively evaluated for decrease in LFB staining (indicative of demyelination) and for increased cellularity in the corpus callosum (indicative of reactive gliosis) (Supplementary Table 2)