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CBS catalyses the conversion of L-homocysteine into L-cystathionine by displacing the OH group of L-serine with the thiol of L-homocysteine in a -replacement reaction to form L-cystathionine, which is subsequently hydrolysed by cystathionine -lyase (CSE) into L-cysteine

All four oncometabolites are formed in the mitochondria (tricarboxylic acid cycle) and can cause similar changes in cancer cells, such as hypermethylation and pseudohypoxia (Dando et al., 2019)