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Male and female GHK-Cu cohorts and saline cohorts had comparable values for escape hole attempts on the first trial, but male and female mice given intranasal GHK-Cu demonstrated fewer escape hole attempts on their final attempt to escape compared to the intranasal saline cohorts (Figure 3C)

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Considering the important functions of vitamin B and the severe consequences associated with its deficiency following bariatric surgery, proper dietary intervention and administration of adequate supplements should be considered to prevent negative clinical outcomes

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PMCID: PMC7605468