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TLR4 downregulation by the RNA-binding protein PUM1 alleviates cellular aging and osteoarthritis

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In vivo studies showed a tumor inhibition rate of 53.99%, higher than the parent inhibitor AT13387 (43%), with reduced toxicity

Clustering of the index-coded samples was performed on a cBot Cluster Generation System using the TruSeq PE Cluster Kit v4-cBot-HS (Illumina) according to the manufacturers instructions

A compromised specific humoral immune response against the SARS-CoV-2 receptor-binding domain is related to viral persistence and periodic shedding in the gastrointestinal tract