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While this research was conducted in a cellular and animal model context rather than a direct weight loss trial, it adds meaningful biological evidence to the idea that B12 status affects metabolic efficiency at the cellular level

Tirzepatide associated with reduced albuminuria in participants with type 2 diabetes: pooled post hoc analysis from the randomized active- and placebo-controlled SURPASS-1-5 clinical trials

The data was analysed using Zetasizer software provided by the manufacturer to obtain hydrodynamic diameter aka z-average diameter (intensity weighted mean diameter derived from cumulant analysis), polydispersity index (dimensionless measure of the broadness of the size distribution calculated from cumulant analysis) and volume fraction (relative amount of different sized particles in separate peaks in a sample solution) 15