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One of the most prominent and extensively studied pathways in DPN pathophysiology is the polyol pathway, which generates an excess of ROS with an oversupply of substrate present during hyperglycemia [27]

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Lifestyle Intervention and Medical Management With vs Without Roux-en-Y Gastric Bypass and Control of Hemoglobin A1c, LDL Cholesterol, and Systolic Blood Pressure at 5 Years in the Diabetes Surgery Study

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