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PMID: 192 VangoitsenhovenRCresciGAM

, Fas ligand (FASLG), tumor necrosis factor (TNF), TNF superfamily member 10 (TNFSF10, also known as TRAIL)) binding their respective receptors, which recruit the adaptor protein Fas associated via death domain (FADD), forming the death-inducing signaling complex (DISC)

Most of the proteins folded and maturated in ER have intra- and/or intermolecular disulfide bonds that are required for their folding and functions, whereas disulfide bond(s) of terminally misfolded proteins in the ER are reduced by the ER-resident reductase ERdj5 followed by retrotranslocation upon ERAD 6,7

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