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The SHMT1 encoded enzyme is cytosolic and the SHMT2 encoded enzyme is mitochondrial

Vasil'eva, E

For those with these conditions, B12 supplements are a vital part of their treatment

Additionally, high ChaC1 expression increases tumor cell sensitivity to anti-tumor drugs by inducing ER stress and ferroptosis (65,69,138)

13 Although BECN1 promotes autophagy in yeast and human cancer cells, loss or haploinsufficiency of BECN1 accelerates tumor formation in mouse models

Thus, protective treatments against oxidative damage with natural antioxidants, may have important biotechnological implications
