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Thus dosage, pharmacokinetics, long-term safety, off-target effects in humans remain unknown

Biochim Biophys Acta 1812: 13591370, 2011

Exposure to PM leads to a decrease in the abundance of Agathobacter and Romboutsia , which exhibit anti-inflammatory activity in the intestines, and an increase in the abundance of proinflammatory bacteria such as Klebsiella , Clostridium , Escherichia , and Haemophilus (86, 87)

Statistics All the statistical analyses and presentations were performed via R software (version 4.1.3)

doi:10.1111/j.1365-313X.2010.04216.x

A synthetic ubiquitin variant (Ubv2.3) was synthesized via NCL, bearing the cyclic deca-arginine CPP, which was incorporated through the Thz linker, resulting in a caged Ubv2.3