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Individuals lacking in B12 can be tormented by symptoms like weakness, tiredness, or even difficulty concentrating and remembering

Without B, methylmalonic acid accumulates and energy production is less efficient

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Histone deacetylases including SIRT1, interact with STAT3 and negatively regulate its transcriptional activity by deacetylating critical lysine residues (Nie et al., 2009)

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Therefore, caution is needed when extrapolating the findings of this work to COVID-19 patients previously vaccinated or infected with SARS-CoV-2 variants