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INTRODUCTION Discoid lupus erythematosus (DLE) is the most common type of chronic cutaneous lupus erythematosus and is categorized by well-demarcated, often hyper or hypopigmented macules or papules that gradually progress...

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Focusing on findings in rodents, Ron and Barak review the intracellular signalling cascades that underlie this transition and the molecular mechanisms that act against it.

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