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The surgical procedure was performed in rats that had food and water ad libitum before the procedure and until the end of the experiment, and assessments were performed by an observer unaware of the treatments used

SHLPs have varying lengths and effects, but none combine rapid nuclear entry with potent modulation of both energy metabolism and redox defense quite like MOTS-C peptide

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Cost: Higher than topical approaches but potentially more cost-effective per result due to improved efficacy

41, BSR20203850

Initial gains may come quickly as inflammation decreases and blood flow improves, but the deeper tissue remodeling required for lasting resolution takes longer