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Of the homozygous mutations most studied, a carrier of the homozygous T677T isoform produces 75% less methyl folate than someone without the mutation, and carriers of the homozygous C1298C isoform produces 17% less methyl folate (Table 1)

doi: 10.1146/annurev.micro.55.1.21 65 RitzD.PatelH.DoanB.ZhengM.AslundF.StorzG.et al

doi: 10.1016/s0006-291x(03)01438-4

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