glutathione stransferase function The S-transferase genes in marine rotifers and copepods: Identification of GSTs and applications for ecotoxicological studies Overexpression of Glutathione S-Transferases in
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20 , e47472 (2019)
Glutathione peroxidase catalyzes reactions in which the enzyme reduces hydrogen peroxide to water, as well as organic hydroperoxides (ROOH) to hydroxy derivatives, resulting in the conversion to the oxidized disulfide form GS-SG: H2O2 + 2GSH = GS-SG + H2O ROOH + 2GSH = GS-SG + ROH +H2O Glutathione peroxidase neutralizes peroxynitrite: ONOO- + 2GSH N2- + GSSG + 22 Glutathione reductase is a flavoprotein with a flavin adenine dinucleotide prosthetic group and consists of two identical subunits
33 In humans, there is evidence of age-related reduction of antioxidant gene expression, observed in the reduced expression of mRNAs coding for SOD1, SOD2 and catalase in the preovulatory follicles of women over the age of 38 years, indicating an age-related reduced defence against ROS
doi: 10.1038/s41569-024-01062-6
[Google Scholar] Boso S., Gago P., Santiago J.-L., Rodrguez-Canas E., Martnez M.-C
