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What they found: Cagrilintide 4.5 mg: 10.8 % weight reduction vs 3.0 % placebo (p 40 % of patients achieved 25 % weight reduction , historically unprecedented Safety profile in line with Phase 2 data Why it matters: REDEFINE 1 confirmed CagriSema as the largest body-weight signal reported in the published incretin literature to date

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Based on these promising findings, axokine, a recombinant human variant of CNTF, was used for testing in humans

Obesity in ageing is associated with blood brain barrier disruption, oxidative stress, neuroinflammation, microglial activation and associated impairment of hippocampus-dependent learning and memory (Tucsek et al., 2014)

I feel like I can hold my bladder longer that I don't have to worry about washroom access

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